Poster Sessions
(PDF file can be downloaded here.)

Posters will be mounted, presented and removed in one of the following groups.

A-group
Category 1: Chemistry for pharmaceuticals A-1 - A-84
2: New drug target A-85 - A-120
8: Regulatory affairs A-121

Mounting: Oct. 14, 15:00-18:00
Presentation: Oct. 15, 12:00-14:00
Removal: Oct. 16, 11:30-12:00

B-group
Category 3: R&D of new chemicals B-1 - B-60
4: Drug metabolism and toxicology B-61 - B-65
5: Drug delivery B-66 - B-73
6: New methods for drug discovery B-74 - B-104
7: Predictive informatics B-105 - B-121
8: Regulatory affairs B-122

Mounting: Oct. 16, 12:30-13:00
Presentation: Oct. 17, 12:00-14:00
Removal: Oct. 17, 17:30-18:00

<Posters; A-group >

A-1 Concise Synthesis of a Muscarine M1 Receptor Antagonist, (-)-TAN1251A
Mizutani H., Takayama J., Soeda Y. and Honda T.
Hoshi University, Japan

A-2 Total Synthesis of Dart-Poison Frog Alkaloids 223A and 205B
Toyooka N., Fukutome A., Nemoto H., Shinoda H., Daly J.W.,# Spande T.F.,# Garraffo H.M.# and Kaneko T.#
Toyama Medical and Pharmaceutical University, Japan, # National Institutes of Health, USA

A-3 Synthesis and Antimicrobial Activity of Novel Globomycin Analogues
Kiho T., Nakayama M., Yasuda K., Miyakoshi S., Inukai M. and Kogen H.
Sankyo Co., Ltd., Japan

A-4 Indolo[1,2-b]indazole Derivatives: Synthesis and Anti-cancer Activity
Katayama H., 1 Zhu Y.-M., 1 Honda T., 1 Kaneko K. 1 and Andoh T. 2
Niigata University of Pharmacy and Applied Life Science, Japan,1 Soka University, Japan 2

A-5 Synthesis and Properties of Rutacarpine and Its Homologues
Park J.-G., Kim S.-I., Kim D.-H., Chang H.-W., Jung H., Lee E.-S. and Jahng Y.
Yeungnam University, Korea

A-6 The Asymmetric Synthesis of a Dopamine D1 Agonist, Dihydrexidine, Utilizing Asymmetric Conjugate Addition of Aryllithium to Nitroolefin
Yamashita M., Yamada K. and Tomioka K.
Kyoto University, Japan

A-7 Stereoselective Horner-Wadsworth-Emmons Reaction for the Synthesis of Amide Isosteres
Sano S. and Nagao Y.
The University of Tokushima, Japan

A-8 Synthesis of Antitumor 6-Alkylidenepenicillanate Sulfones and Related 3-Alkylidene-2-Azetidinones
Vorona M., Veinberg G., Shestakova I., Kanepe I. and Lukevics E.
Latvian Institute of Organic Synthesis, Latvia

A-9 Novel Indium-Mediated Radical Cyclizations and Applications to Synthesis of HIV Protease Inhibitors
Yanada R.,1 Nishimori N.,1 Matsumura A.,1 Obika S.,1 Mitsuya H.,2,3 Fujii N.1 and Takemoto Y.1
1Kyoto University, Japan, 2Kumamoto University, Japan, 3National Institute of Health, USA

A-10 A Second-Generation Synthesis of the Squalene Synthase Inhibitor Zaragozic Acid C
Nakamura S., Hirata Y., Kurosaki T., Anada M. and Hashimoto S.
Hokkaido University, Japan

A-11 Electrochemical Synthesis of Complex Polycyclic Ring Systems as Useful Intermediates for the Synthesis Biologically Active Compounds
Ilangovan A., Toyota M. and Ihara M.
Tohoku University, Japan

A-12 Highly Efficient ortho-Fluoro-dimeric Cinchona-derived Phase-transfer Catalysts
Park H.-G., Choi S.-H., Kim M.-J., Lee J., Jeong B.-S., Yoo M.-S., Lee J.-H., Park B.-S., Kim M.-G. and Jew S.-S.
Seoul National University, Korea

A-13 Highly Enantioselective Synthesis of α-Alkyl-alanine via the Catalytic Phase-Transfer Alkylation of 2-Naphthyl Aldimine tert-Butyl Ester by Using O(9)-Allyl-N(1)-2',3',4'-trifluorobenzylhydrocinchonidinium Bromide
Jew S.-S., Lee J.-H., Lee Y.-J., Yoo M.-S., Jeong B.-S. and Park H.-G.
Seoul National University, Korea

A-14 Efficient and Convergent Synthesis of Enantio-pure 2α - and 2β -Alkylated 1α,25-Dihydroxy-19-norvitamin D3 with High Potency in Induction of HL-60 Cell Differentiation
Ono K., Yoshida A., Saito N., Fujishima T., Honzawa S., Suhara Y., Kishimoto S., Sugiura T., Waku K., Takayama H. and Kittaka A.
Teikyo University, Japan

A-15 Dirhodium(II) tetrakis[N-tetrachlorophthaloyl-(S)-tert-leucinate]: A New Chiral Rh(II) Catalyst for Enantioselective Benzylic C-H Amidations
Yamawaki M., Tsutsui H., Anada M. and Hashimoto S.
Hokkaido University, Japan

A-16 Concise Syntheses and Biological Activities of 2α-Substituted 20-epi-1α,25-Dihydroxyvitamin D3
Honzawa S.1, Suhara Y.1, Saito N.1, Kishimoto S.2, Fujishima T.1, Kurihara M.3, Sugiura T.2, Waku K.2, Takayama H.1 and Kittaka A.1
1,2 Teikyo University, Japan, 3National Institute of Health Sciences, Japan

A-17 An Asymmetric Total Synthesis of (-)-Galanthamine
Kodama S., Hamashima Y., Takita H., Nishide K. and Node M.
Kyoto Pharmaceutical University, Japan

A-18 Development of a Novel Sugar Linkage: 6,6'-Ether-Connected Sugars
Takahashi H.1, Fukuda T.1, Miyamoto H.2, Ohkura Y. 2 and Ikegami S.1
1Teikyo University, Japan, 2 KOTOBUKI Pharmaceutical Co., Ltd., Japan

A-19 Construction of Indole Library for Serotonin Related Drugs in Solid-Phase Reaction
Mun H.-S., Bae N.-M. and Jeong J.-H.
Kyung Hee University, Korea

A-20 Synthesis of Selenoflavonoid
Kim D.-M. and Jeong J.-H.
Kyung Hee University, Korea

A-21 Macrolactonization of ω-Hydroxy Esters from Selenolester Intermediate
Shen L.-L. and Jeong J.-H.
Kyung Hee University, Korea

A-22 Design, Synthesis, and Evaluations of PKC Inhibitor Containing Phorbol Structure
Wada R., Suto Y., Kanai M. and Shibasaki M.
The University of Tokyo, Japan

A-23 Asymmetric Synthesis of (+)-Polyoxamic Acid
Joo J.-E., Lee Y.-S., Lee K.-H., Lee K.-Y. and Ham W.-H.
Sungkyunkwan University, Korea

A-24 Total Synthesis of Deoxy-azasugars
Pyun S.-J., Lee K.-Y. and Ham W.-H.
Sungkyunkwan University, Korea

A-25 Total Synthesis of (-)-Swainsonine
Pyun S.-J., Oh C.-Y., Kim Y.-H. and Ham W.-H.
Sungkyunkwan University, Korea

A-26 Study on the Total Synthesis of Manzacidin B
Lee Y.-S., Kim Y.-H., Oh C.-Y. and Ham W.-H.
Sungkyunkwan University, Korea

A-27 Novel Regioselective and Stereoselective Synthesis of 1,2-Aminoalcohols using Chlorosulfonyl Isocyanate and Its Application to the Total Synthesis of (-)-Cytoxazone
Jung Y.-H., Kim J.-D. and Zee O.-P.
Sungkyunkwan University, Korea

A-28 Memory of Chirality in Intramolecular Conjugate Addition of Enolates: A New Route to Highly Substituted Chiral Nitrogen-Containing Heterocycles from α-Amino Acids
Majumdar S. and Kawabata T.
Kyoto University, Japan

A-29 Synthesis of (+)-Brefeldin A, an Anti-apoptotic Agent
Suh Y.-G.,a Paek S.-M.,a Seo S.-Y.,a Han Y.-T.,a Kim S.-H.a and Jung J.-K.b
aSeoul National University, Korea, bChungbuk National University, Korea

A-30 A Facile Asymmetric Synthesis of Tetrahydroisoquinoline and Tryptoline Derivatives with a Quaternary Carbon Center at C(3)
Ozturk O., Shimada S. and Kawabata T.
Kyoto University, Japan

A-31 Design and Total Synthesis of Epothilone Analogs
Nakama C., Namme R., Sawada D., Ohshima T. and Shibasaki M.
The University of Tokyo, Japan

A-32 Total Synthesis of Apoptosis Inhibitor Bongkrekic Acid
Sugioka T., Umaba Y., Shindo M. and Shishido K.
University of Tokushima, Japan

A-33 Structure and Function of Synthetic Heme Thiolate Complexes
Okuzono K.1, Yamazaki K.1, Umezawa N.1, Izumi Y.2 and Higuchi T.1
1Nagoya City University, Japan, 2Tokyo Institute of Technology, Japan

A-34 Medicinal Substance from the Industrial Waste
Tadjimukhamedov Kh.S., Akhmedov K.N., Kholikov T.S. and Radjabova Kh.A.
National University of Usbekistan, Usbekistan

A-35 Against the Yeast Malassezia furfur, Isolaton and Identification of an Antibacterial Compound from Polygonum tinctorium
Kitahara H.1, Kumazawa K.1, Ishikawa D.1 and Fukui T.2
1. Hirosaki University, Japan, 2. Byotai-seiri Laboratory, Japan

A-36 Study on Unpleasant Foot Smell, the Smell Producing Bacteria and the Use of Some Essential Oil as Antibacterial Agent
Maneewan A., Kannka T. and Chairote G.
Chiang Mai University, Thailand

A-37 Search for New Selective Anti-Helicobacter Pylori Compounds from Brazilian Medicinal Plants
Ohsaki A.1, Isobe T.2, Nagata K.2 and Takashima J.3
1Tokyo Medical and Dental University, Japan, 2Hyogo College Medicine, Japan, 3Mitsubishi Pharma Corporation, Japan

A-38 A New Antinociceptive Agent From Matrine-Type Alkaloids as a Lead Compound
Takeuchi Y., Terado Y., Kobashi S., Mizuo K., Yamauchi T., Kubo H., Narita M., Kamei J., Suzuki T. and Higashiyama K.
Hoshi University, Japan

A-39 New Class of Pancreatic Lipase Inhibitors Abietane-Type Diterpenes from Sage
Yoshikawa M.,1 Ninomiya K.,1 Shimoda H.,1 Kasajima N.,1 Morikawa T.,1 Nishida N.,2 Yoshino T.,2 Kawahara Y. 2 and Matsuda H.1
1Kyoto Pharmaceutical University, Japan, 2Morishita Jintan Co. Ltd., Japan

A-40 Hepatoprotective Amide Constituents from the Fruit of Piper chaba
Matsuda H., Ninomiya K., Yamaguchi I., Morikawa T. and Yoshikawa M.
Kyoto Pharmaceutical University, Japan

A-41 New Skeletal Flavonoids with Hepatoprotective Activities from the Desert Plant Anastatica hierochuntica
Morikawa T., Xu F., Ninomiya K., Matsuda H. and Yoshikawa M.
Kyoto Pharmaceutical University, Japan

A-42 Construction of a Chemical Library of Unnatural Polyketides by Plant Polyketide Synthases
Abe I., Morita H., Takahashi Y., Lou W. and Noguchi H.
University of Shizuoka, Japan

A-43 Novel Lanosterol Synthase Inhibitors from Microbial Origin
Sakano Y., 1,3 Shibuya M.,1 Tomoda H., 2 Omura S. 2 and Ebizuka Y. 1
1 The University of Tokyo, Japan, 2 Kitasato University, Japan, 3 University of Shizuoka, Japan

A-44 Antioxidant Effects of 3,5,7,4'-Tetrahydroxy-2'-Methoxyflavone and Related Flavonoids on Lipid Peroxidation; Requirements for Antioxidant Activity
Yokoyama S. 1 and Takeda T. 2
1 Kyushu University of Health and Welfare, Japan, 2 Kyoritsu College of Pharmacy, Japan

A-45 Planar Catechin Analogue as a New Type of Synthetic Antioxidant
Fukuhara K.1, Nakanishi I.2,3, Hakamata W.1, Ohkubo K.3, Miyazaki K.1,4, Urano S.4, Miyata N.5, Ozawa T.2, Fukuzumi S.3, Ikota N.2 and Okuda H.1
1National Institute of Health Sciences, Japan, 2National Institute of Radiological Sciences, Japan, 3Osaka University, CREST, Japan Science and Technology Corporation, Japan, 4Shibaura Institute of Technolgy, Japan, 5Nagoya City University, Japan

A-46 New Inhibitor for Receptor of Nuclear Export Signal from Medicinal Plants
Tamura S.1, Ye Y.1, Kawanishi M.1, Kohno M.2, Shioda T. 3, Yoshida M.4, Kobayashi M.1 and Murakami N.1
1Osaka University, Japan, 2Nagasaki University, Japan, 3Osaka University, Japan, 4RIKEN Institute, Japan

A-47 Anti-malarial Constituent from Spicy Medicinal Plant from Southeast Asia
Tamura S., Huq M.M., Horii T. and Murakami N.
Osaka University, Japan

A-48 Anti-malarial Principles from Central African Medicinal Plants
Tamura S.1, Syamsurizal1, Kubata B.K.2, Horii T.1 and Murakami N.1
1Osaka University, Japan, 2Osaka Bioscience Institute, Japan

A-49 Mechanisms of Radical-scavenging Reactions of Antioxidative Polyphenolic Flavones
Nakanishi I.,1,2 Ohkubo K.,2 Miyazaki K.,3,4 Urano S.,4 Okuda H.,3 Ozawa T.,1 Fukuzumi S.,2 Fukuhara K.3 and Ikota N.1
1National Institute of Radiological Sciences, Japan, 2Osaka University, CREST, Japan Science and Technology Corporation, Japan, 3National Institute of Health Sciences, Japan, 4Shibaura Institute of Technolgy, Japan

A-50 cDNA Cloning of Dammarenediol II Synthase from Hairy Root Cultures of Panax ginseng
Shibuya M., Tansakul P., Kushiro T. and Ebizuka Y.
The University of Tokyo, Japan

A-51 Design, Synthesis and Biological Activities of Novel Vanilloid Receptor Antagonists
Suh Y.-G.,a * Kim J.-K.,a Min K.-H. ,a Lee B.-Y.,a Lee Y.-S.,a Kim S.-H.,a Lee K.-O.,a Seung H.-S.,a Park Y.-H.b and Joo Y.-H.b
aSeoul National University, Korea, bPacific R&D Center, Korea

A-52 Cloning and Functional Analysis of Alternaria solani Reduced-complex Type PKS Genes
Kasahara K.1, Fujii I.1, Ebizuka Y.1 and Oikawa H.2
1University of Tokyo, Japan, 2Hokkaido University, Japan

A-53 Polyketide Synthase Genes from a Topopyrone Producing Strain of Phoma sp
Kashiwa N., Fujii I. and Ebizuka Y.
University of Tokyo, Japan

A-54 Lead Compounds from Zulu Traditional Medicine
Mulholland D.A.1, Crouch N.R.,1,2 Langlois A.,1 Koorbanally C.,1 Ndlovu E. 1 and du Toit K.1
1University of Natal, South Africa, 2National Botanical Institute, South Africa

A-55 To Problem for Natural Resource Use of Taxifoine
Selenge D.1, Enkhtur A.1, Solongo A.1 and Gerelt-Od Ya.2
1. Institute of Chemistry and Chemical Technology, Mongolia, 2. National University of Mongolia, Mongolia

A-56 On the Investigation of Genera Gentiana L Family Gentianaceae Growing in Mongolia
Oyun Kh., Purev O., Tankhaeva L.M. and Nikolaeva G.G.
Institute of Chemistry and Chemical Technology MAS., Mongolia, Institute of Expermental Biology RAS, Russia

A-57 Potential Topoisomerase II-Mediated Antitumor Agents, 5-(9-Acridinylamino)toluidine Derivatives
Su T.-L., Lin C.-F.,1,2 Chang J.-Y.,3 Chen C.-H.,1 Cheng S.-Y.,1 Chen K.-T.,2 Bacherikov V. 1 and Chou T.-C.4
1 Academia Sinica, Taiwan, 2 Taipei Medical University, Taiwan, 3 NHRI, Taiwan, 4 Memorial Sloan-Kettering Cancer Center, USA

A-58 Novel Phosphodiesterase 5 Inhibitors, Nitrobenzamide Derivatives
Mizutani T., Sawada K., Kuroda A., Inoue T., Urano Y., Kayakiri N., Sawada Y., Hosogai N., Oku T. and Tanaka H.
Fujisawa Pharmaceutical Co., Ltd., Japan

A-59 Solution Phase Generation of Diverse Small Molecular Compound Libraries and Their Inhibition of TNF-α Stimulation by LPS on Macrophage in vitro
Liu G., Zhang L., Zhang S.-D., Wu X.-H., Sun G.-C. and Kou B.-B.
Institute of Materia Medica, P.R. China

A-60 MCC-134 Derivatives as Activators of β-Cell Type KATP Channel
Dhanda A., Nielsen F.E., Arkhammar P.O.G., Wahl P. and Hansen J.B.
Novo Nordisk A/S, Denmark

A-61 2'-Benzyloxychalcone Derivatives Stimulate Glucose Uptake in 3T3-L1 Adipocytes
Kamei R.1, Kadokura M.1, Kitagawa Y.1, Hazeki O.2 and Oikawa S.1
1Daiichi Suntory Biomedical Research Co., LTD., Japan, 2Hiroshima University, Japan

A-62 A Selective Human Histamine H4-receptor Agonist; 2-Cyano-1-methyl1-3-{(2R,5R)-5-[1H-imidazol-4(5)-yl]tetrahydrofuran-2-yl}methylguanidine (OUP-16)
Harusawa S.,1 Hashimoto T.,2 Araki L.,1 Zuiderveld O.P.,3 Smit M.J.,3 Terashima H.,1 Kawamura M.,1 Yamamoto Y.,2 Sakamoto Y.,4 Kurihara T.,1 Leurs R.,3 Bakker R.A.3 and Yamatodani A.2
1Osaka University of Pharmaceutical Sciences, Japan, 2Osaka University, Japan, 3Vrije Universiteit, The Netherlands, 4Azwell, Inc., Japan

A-63 KRP-103, A Novel Pyrimidine Derivative with NK1 Antagonist Activity: Synthesis and Structure-Activity Relationships
Seto S., Tanioka A., Ikeda M. and Izawa S.
Kyorin Pharmaceutical Co., Ltd., Japan

A-64 The Hypoglycemic Effect of Quinolizine Compounds
Inoue M., Kubo H., Yamauchi T. and Higashiyama K.
Hoshi University, Japan

A-65 Design and Synthesis of Heterocyclic Compounds Fused with Triazolopyrimidines as a Xanthine Oxidase Inhibitor
Nagamatsu T.,a Ahamed S.a and Endo K.b
aOkayama University, Japan, bYamasa Co., Japan

A-66 Structure-Activity Relationships of New Synthetic Isoprenoids to Overcome Taxol Resistance
Inomata K.,1 Suzuki S.,1 Endo Y., 1 Enokida H. 2 and Nakagawa M. 2
1Tohoku Pharmaceutical University, Japan, 2Kagoshima University, Japan

A-67 CoMFA and CoMSIA 3D QSAR Studies on Pimarane Cyclooxygenase-2 (COX-2) Inhibitors
Suh Y.-G.,a Lee K.-O.,a Park H.-J.,b Kim Y.-H.,c Shin D.-Y.,a Seo S.-Y.,a Lee Y.-S.a and Moon S.-H.a
aSeoul National University, Korea, bSungkyunkwan University, Korea, cChungnam University, Korea

A-68 The Structure-Activity Relationship of Mansonone F, a Potent Anti-MRSA Sesquiterpenoid Quinone: Insights into Minimum Structural Requirements and SAR of C3 Position
Suh Y.-G., Shin D.-Y., Jung J.-H., Chae J.-H., Hyun S.-S. and Paek S.-M.
Seoul National University, Korea

A-69 A Novel and Highly Potent Non-vanilloid VR Antagonist
Suh Y.-G.,a Lee Y.-S.,a Min K.-H.,a Kim J.-K.,a Lee B.-Y.,a Park O.-H.,a Seung H.-S., a Moon S.-H., a Oh U.-T.,a Park Y.-H.b and Joo Y.-H.b
aSeoul National University, Korea, bPacific R&D Center, Korea

A-70 Opioid Peptide Analogues Containing β-Pro Show Antinociceptive Activity after Periphereal Administration
Cardillo G., Gentilucci L., Tolomelli A., Calienni M., Qasem A. and Spampanato S.
University of Bologna, Italy

A-71 Novel Strategy for Development of Virus Entry Inhibitors
Otaka A.,a Kodama E.,a Tamamura H.,a Matsuoka M.,a Yamamoto N.b and Fujii N.a
a Kyoto University, Japan, bTokyo Medicinal and Dental University, Japan

A-72 Synthesis of New Polyether Macrocycles Containing Acylurea Structure and Application to Calcium Selective Chemosensor
Aoki Y., Asano Y., Nagai S. and Higuchi T.
Nagoya City University, Japan

A-73 A Mild and Versatile Ketone Synthesis using Thiol Esters
Miyazaki T., Yokoshima S., Yamashita T., Tokuyama H. and Fukuyama T.
The University of Tokyo, Japan

A-74 Synthetic Study of Pyrrole-imidazole Alkaloids, Marine Natural Products Having Various Biological Activities
Kawasaki I., Khadeer A., Sakaguchi N., Kakuno A., Morimoto T., Yamashita M. and Ohta S.
Kyoto Pharmaceutical University, Japan

A-75 Novel Antibacterial Macrolides: Synthesis of 15-membered Diolides
Ohara T., Kume M., Narukawa Y., Motokawa K. and Uotani K.
Shionogi & Co., Ltd., Japan

A-76 A New Synthetic Route and Structure Activity Relationships of Acetomycin and Its Analogues
Uenishi J.,a Muraoka N.,a Uchida M.,a Ikeda D.,a Kawatsura M.a and Yamori T.b
a Kyoto Pharmaceutical University, Japan, b Japanese Foundation of Cancer Research, Japan

A-77 MexAB-OprM Specific Efflux Pump Inhibitors in Pseudomonas aeruginosa: Discovery and Early Strategies for Lead Optimization
Nakayama K.,a Ishida Y.,a Ohtsuka M.,a Kawato H.,a Yoshida K.,a Ohta T.,a Hoshino K.,a Ishida H.,a Ohtani T.,a Kurosaka Y.,a Renau T.E.,b Leger R.,b Zhang J.Z.,b Lee V.J. b and Watkins W. J. b
a Daiichi Pharmaceutical Co., Ltd., Japan, b Essential Therapeutics, Inc., USA

A-78 Chemistry and Biology of Khafrefungin. Total Synthesis, Design, and Structure-activity Relationship of Khafrefungin, an Antifungal Agent
Mori Y.,1 Nakamura M.,1 Okuyama K.,1 Tanikawa K.,1 Yasuda S.,2 Hanada K.2 and Kobayashi S.1
1The University of Tokyo, Japan, 2National Institute of Infectious Diseases, Japan

A-79 Studies on the Synthetic Process of Perindopril
Yao S.-Y., Liu D., Guo J.-N., Dai X.-P. and Zhao L.-X.
Shenyang Pharmaceutical University, P.R. China

A-80 Structural Modification of Boswellic Acid as Anti-tumor Drugs
Meng Y.-Q.1,2, Liu D.1, Zhang Y.-H., Jing Y.-K.3 and Zhao L.-X.1
1.Shenyang Pharmaceutical University, P.R. China, 2. Shenyang Institute of Chemical Technology, P. R. China, 3. Mount Sinai School of Medicine, USA

A-81 Studies on Synthesis of Furostan Saponins and Their Anticancer Activities
Cheng M.-S.1, Liu Y.-X.1, Wang Q.-L.1, Liu Y.1, Lin B.1, Yang Z.2 and Yao X.-S.1
1Shenyang Pharmaceutical University, P.R. China, 2 Ministry of Education, Peking University, P.R. China

A-82 Design, Synthesis, and Biological Activities of Novel Inhibitors of Plasminogen Activator Inhibitor-1 (PAI-1) Production
Yamamoto Y., Sai H., Ogiku T., Ohmizu H., Murakami J. and Ohtani A.
Tanabe Seiyaku Co., Ltd., Japan

A-83 Synthesis and Reactions of Some New Thiocarbamoyl Derivatives of Pharmaceutical Interest
Metwally M.A.
University of Mansoura, Egypt

A-84 Synthesis of Some New Arylazo Derivatives of Physiological Properties
Sadek E.G.
University of Mansoura, Egypt

A-85 Phenylcarbamates and Choline Phenyl Ethers as Subtype-selective Ligands for Nicotinic Acetylcholine Receptors (nAChRs)
Andrae M., Tilotta C.M. and Gundisch D.
Rhein. Friedr.-Wilh. University, Germany

A-86 Structure of Trypanosoma brucei Prostaglandin F2α Synthase: H+-transfer by the Catalytic Monad Lysine
Okano Y.2, Inoue T.2,3, Kubata B.K.1, Kabututu Z.1, Munday C.J.1, Duszenko M.4, Martin S.K.5, Lazarus M.1, Toh H.6, Matsumura H.2, Kai Y.2 and Urade Y.1
1Osaka Bioscience Institute, Japan, 2Osaka University, Japan, 3PRESTO, JST, Japan, 4Universitat Tubingen, Germany, 5United States Army Medical Research Unit-Kenya, USA, 6Biomol. Eng. Res. Institute, Japan

A-87 Computer System Pass as a Promising Tool for Finding New Ligands of G-Protein Coupled Receptors
Levchenko M.E., Poroikov V.V. and Filimonov D.A.
Institute of Biomedical Chemistry RAMS, Russia

A-88 Development of the Inhibitor Considering the Mg2+ Activation Mechanism of Human Prostaglandin D Synthetase
Inoue T.1,2, Aritake K.3, Katsuyama N.1, Okano Y.1, Matsumura H.1, Kai Y. 1 and Urade Y.3
1Osaka University, Japan 2PRESTO, Japan Science and Tech. Corp., Japan 3Osaka Bioscience Institute, Japan

A-89 Antisense 2',4'-BNA Oligonucleotide Targeting the Stem Region of Hepatitis C Virus RNA Inhibits Gene Expression
Obika S.,1 Tanabe A., 1 Eguchi K., 1 Une D., 1 Uchida M., 1 Ohsugi Y., 2 Doi T. 1 and Imanishi T. 1
1. Osaka University, Japan, 2. Chugai Pharmaceutical Co., Ltd., Japan

A-90 The Role of ASK1 for Aβ-induced Neuronal Cell Death
Kadowaki H.1,2, Nishitoh H.1,2, Urano Y.1, Nagano T.1 and Ichijo H.1,3
1University of Tokyo, Japan, 2Tokyo Medical and Dental University, Japan, 3CREST-JST, Japan

A-91 Metal Chelations of Candidate Compounds for Prion Disease Treatments
Fukuuchi T.1, Okuda K.1, Doh-ura K.2 and Ohta S.1
1 Hiroshima University, Japan, 2 Kyushu University, Japan

A-92 Establishment of a New in vitro Culture using Transgenic Drosophila to Assess Innate Immunity and Its Application to Search for New Immune Regulators from Natural Resources
Ueda K., Kikuchi H., Kurata S. and Oshima Y.
Tohoku University, Japan

A-93 Chain-branched Acyclic Phenethylthiocarbamates as Vanilloid Receptor Antagonists
Kim H.-D., a Yoon J.-W., a Choi H.-Y. a and Park Y.-H.b
aSookmyung Women's University, Korea, bAmorePacific R & D Center, Korea

A-94 Synthesis and Biological Evaluation of Dual Na+ and Ca2+ Channel Blockers with Antioxidant Activity: Discovery of the Novel Neuroprotectant SUN N8075
Nakanishi K.1, Toba T.1, Horikawa-Tamura Y.1, Tamura S.1, Imajo S.1, Ohishi H.2 and Annoura H. 1
1Daiichi Suntory Biomedical Research Co., Ltd., Japan, 2Osaka University of Pharmaceutical Science, Japan

A-95 Neuroprotective or Neurotoxic Effect of 1-Methyl-1,2,3,4-Tetrahydroisoquinoline and Related Compounds on Cultured Neuronal Cells
Okuda K., Kotake Y. and Ohta S.
Hiroshima University, Japan

A-96 Structure-activity Relationship of the Novel N3-substituted Uridines Exhibiting Antinociceptive Activity
Shimizu T.1, Kimura T.1, Funahashi T.1, Watanabe K.1, Ho I.-K.2, Maruyama T.3 and Yamamoto I.3
1Hokuriku University, Japan, 2University of Mississippi Medical Center, U.S.A., 3Kyushu University of Health and Welfare, Japan

A-97 Synthetic Study of Pyridinium Retinoids for Probing GPCR Functions
Furuta T., Matsuzawa Y., Asakawa T. and Tanaka K.
University of Shizuoka, Japan

A-98 A Potent and Selective Catecholaminergic and Serotoninergic Activity Enhancer (R)-(-)-1-(Benzofuran-2-yl)-2-propylaminopentane [(R)-(-)-BPAP] and Its Derivatives: Synthesis and Activity
Oka T., Yasusa T., Watanabe M., Nakatani M., Shimazu S., Sato N. and Yoneda F.
Fujimoto Pharmaceutical Research, Inc., Japan

A-99 N-Hydroxyformamidine Derivatives as a Selective 20-HETE Synthase Inhibitors
Kakinuma H., Amada H., Kobayashi-Matsunaga Y., Ishii T., Nakamura T., Miyata N., Taniguchi K., Omura T., Koda A., Bando K., Kametani S. and Sato M.
Taisho Pharmaceutical Co., Ltd., Japan

A-100 Discovery and Optimization of Potent Orally Active Small Molecular Thrombin Receptor(PAR-1) Antagonists
Kawahara T., Suzuki S., Kogushi M., Matsuoka T., Kobayashi H., Hishinuma I. and Kajiwara A.
Eisai Co., Ltd., Japan

A-101 A Novel Class of NF-κB Inhibitors: Synthesis and Structure-Activity Relationships of Oxybenzoic Acids with Quinon Core Structure
Ogou N.1, Suzuki K.2, Furuya M.1, Mizuno A.3 and Nunokawa Y.1
1Daiichi Suntory Biomedical Research Co., Ltd., Japan, 2Suntory Co., Ltd., Japan, 3Daiichi Suntory Pharma Co., Ltd., Japan

A-102 Dehydroabietic Acid Derivatives as a Novel Scaffold for Large Conductance Calcium-Activated K+ Channel Openers
Nonomura T.,1 Ohwada T.,1 Sakamoto K.,2 Hotta A.,2 Ohya S.2 Muraki K.2 and Imaizumi Y.2
1 The University of Tokyo, Japan, 2 Nagaya City University, Japan

A-103 Structural Design and Synthesis of Nitric Oxide Donors Aimed to Controlled Release of NO
Ohwada T. and Uchiyama M.
The University of Tokyo, Japan

A-104 Synthesis and Structure-activity Relationships of 2-Amino-6-(2-hydroxyphenyl)nicotinonitrile Derivatives as IKK-β Inhibitors
Murata T., Fuchikami K., Komura H., Umeda M. and Ziegelbauer K.B.
Bayer Yakuhin, Ltd., Japan

A-105 Selective Inhibition of Human Inducible Nitric Oxide Synthase by L-Arginine Analog-containing Dipeptides
Higuchi T.1, Park J.-M.2 and Nagano T.2
1) Nagoya City University, Japan, 2) The University of Tokyo, Japan

A-106 Synthesis of Heterocyclic Carboxamide Derivatives and Their Inhibitory Activities against Protein Kinase C
Suzuki T., Onda K., Murakami T., Negoro K., Maruyama T., Yokono M., Shimaya A., Ohta M. and Tsukamoto S.
Yamanouchi Pharmaceutical Co., Ltd., Japan

A-107 DPP-IV Inhibitors: Synthesis and Evaluation of 3- or 4-Substituted 2-Cyanopyrrolidines
Takahashi M., Hiratate A., Kitano K., Yamamoto K. and Fukushima H.
Taisho Pharmaceutical Co., Ltd., Japan

A-108 Discovery of Novel Benzimidazoles as Potent Inhibitors of Tie-2 Tyrosine Kinase Receptor
Hasegawa M., Nishigaki N., Washio Y., Kano K., West R.1, Harris P.2, Mui C.2, Sato H., Veal J.2, Shewchuk L.2 and Mori I.
GlaxoSmithKline Tsukuba Research Labs, Japan, 1GlaxoSmithKline Stevenage, UK, 2GlaxoSmithKline RTP, USA

A-109 Syntheses of Protein Tyrosine Phosphatase Inhibitors and These Clinical Applications for Neuroblastoma
Asami S.1, Horikawa A 1, Tsurumi Y.1,2, Miyamoto T.1, Hino H.1, Toriyama M.1, Miyake M. 1, Kimura Y.1, Akihisa T.1, Sato T.3, Chin M.1, Mugishima H.1, Uchikura K.1, Motohashi S.1 and Suzuki T.1
1 Nihon University, Japan, 2 Toko Pharmaceutical Industrial Co., Ltd., Japan, 3 Science University of Tokyo, Japan

A-110 Synthesis of Sialic Acid Derivatives Structurally Modified at C-4 Position and Their Behaviour towards Sialidase from Human Parainfluenza Virus Type 1
Ikeda K., Kitani S., Sato K., Hosokawa C., Suzuki T., Suzuki Y., Tanaka K. and Sato M.
University of Shizuoka, Japan

A-111 Design and Synthesis of Ligands for Nuclear Receptors; VDR and RAR
Kurihara M.1, Sato Y. 1, Nomoto S. 1, Okuda H. 1, Honzawa S. 2, Saito N. 2, Suhara Y. 2, Fujishima T.2, Takayama H. 2 and Kittaka A. 2
1National Institute of Health Sciences, Japan, 2Teikyo University, Japan

A-112 Synthesis and Structure-Activity Relationships of Potent and Selective EP2-Receptor Agonists
Tani K., Naganawa A., Ishida A., Sagawa K., Ogawa M., Maruyama T., Ohuchida S., Toda M. and Kondo K.
Ono Pharmaceutical Co., Ltd., Japan

A-113 Design and Synthesis of β-pompilidotoxin Analogs That are Candidates for Neuroprotective Agents under Ischemic Conditions
Nakayama H., Yokote S., Shimizu E., Shirasaki T. and Takahama K.
Kumamoto University, Japan

A-114 Anti-oxidative Activity of Nitroxyl Radical in Gastric Mucosal Lesion in Rats
Yasukawa K., Soeda T., Shigemi R. and Utsumi H.
Kyushu University, Japan

A-115 Nitroxyl Spin Probes for in vivo ESR Measurement of Cerebrovascular ROS Generation
Yamato M. and Utsumi H.
Kyushu University, Japan

A-116 Hypoxic Cerebral Ischemia Induced Upregulation of Endoplasmic Reticulum-associated Degradation Related Molecule HRD1 in the Mouse Brain
Qi X., Okuma Y., Kaneko M., Hosoi T. and Nomura Y.
Hokkaido University, Japan

A-117 Discovery and Development of JTT-705, a Potent Cholesteryl Ester Transfer Protein (CETP) Inhibitor
Maeda K., Okamoto H., Uchida I., Haruta J. and Shinkai H.
Japan Tabacco Inc., Japan

A-118 Depletion of Glutathione and Apoptosis of Tumor Cells
Wang J.-L.1, Liang J.-J.1, Hu Q.-Z.1, Jing Y.-K.2 and Zhao L.-X.1
1. Shenyang Pharmaceutical University, P. R. China, 2. Mount Sinai School of Medicine, USA

A-119 The Novel Drug Development: Pyrazoles as Anti-Invasive Drugs
Kumar A.a,b, Parmar V.S.a, Jha H.N.b, Olsen C.E.c and Mareel M.M.d
aUniversity of Delhi, India, bMMH College, India, cRoyal Veterinary and Agricultural University, Denmark, dUniversity Hospital, Gent, Belgium

A-120 Role of Zinc Finger in Nuclear Transport of Transcription Factor Sp1
Kuwahara J., Ito T., Yamano Y. and Itoh K.
The University of Tokushima, Japan

A-121 Issues Related to Quality Evaluation of New Drug Substances and Drug Products
Shimazawa R., Nagata R., Okuda H. and Toyoshima S.
National Institute of Health Sciences, Japan

<Posters; B-group >

B-1 Synthesis and Antifungal Activity of FX0549 and Related Compounds
Setsu F., Umemura E., Sasaki K., Tadauchi K., Wakiyama Y., Okutomi T., Ohtsuka K., Takahata S., Atsumi K. and Ajito K.
Meiji Seika Kaisha, Ltd., Japan

B-2 FX0685, A New Triazole Antifungal Agent: Synthesis and Structure-activity Relationships of Novel Triazole Containing an Imidazo[2,1-b]thiazole Carboxamide Moiety
Umemura E., Sasaki K., Setsu F., Tadauchi K., Okutomi T., Ohtuka K., Takahata S., Atsumi K. and Ajito K.
Meiji Seika Kaisha, Ltd., Japan

B-3 Development of New Antimalarial and Antileishmanial Agents Based on DLC Strategy
Takasu K., Terauchi H., Shimogama T., Kasai K., Inoue H. and Ihara M.
Tohoku University, Japan

B-4 Antimicrobial Activity of Cationic Fullerene Derivatives
Nishikawa D., Ikegami N., Takahashi K., Endo T., Mochizu-ku M. and Mashino T.
Kyoritsu College of Pharmacy, Japan

B-5 Syntheses and Structure-Activity Relationships of Macrolide Antibiotics Including Arylsulfonamido- and Arylamino-linkers

Manaka A., Kashimura M., Tanikawa T., Ishii T., Sugimoto T., Suzuki K., Akashi T. and Asaka T.
Taisho Pharmaceutical Co., Ltd., Japan

B-6 TAK-599, a Novel N-Phosphono Prodrug of Anti-MRSA Cephalosporin T-91825: Synthesis, Physicochemical and Pharmacological Properties
Ishikawa T., Matsunaga N., Tawada H., Kuroda N., Nakayama Y., Ikeda Y., Tagawa Y., Iizawa Y., Okonogi K., Hashiguchi S. and Miyake A.
Takeda Chemical Industries, Ltd., Japan

B-7 Synthesis of Novel Anti-HIV 4'-substituted Purine Nucleosides in order to Reduce Toxicity and/or to Improve Metabolic Stability in vivo
Kitano K.1, Kohgo S.1, Yamada K.1, Ashida N.1, Sakata S.1, Hayakawa H.1, Kodama E.2, Mitsuya H.3 and Ohrui H.4
Yamasa Corporation, Japan1, Kyoto University, Japan2, Kumamoto University, Japan3, Tohoku University, Japan4

B-8 Potent Tripeptide-type HIV-1 Protease Inhibitors Containing Tfg at the P2 Position
Rajesh S., Hidaka K., Wang J., Ami E., Kimura T., Hayashi Y. and Kiso Y.
Kyoto Pharmaceutical University, Japan

B-9 Identification of Dipeptide-type HIV-1 Protease Inhibitors with High Antiviral Activity
Kimura T., Hidaka K., Tanaka Y., Matsumoto H., Matsui Y., Abdel-Rahman H.M., Hayashi Y. and Kiso Y.
Kyoto Pharmaceutical University, Japan

B-10 Interferon Inducing Activity of 2,8-Disubstituted 9-Benzyladenines
Sajiki H., Kazaoka K. and Hirota K.
Gifu Pharmaceutical University, Japan

B-11 Discovery of Orally Active Peptidomimetic Motilin Antagonist
Yoshino H., Sato T., Imaoka I., Kotake K., Kumagai Y., Kamei K., Takanashi H., Sato H., Matsuoka H. and Kozono T.
Chugai Pharmaceutical Co., Ltd., Japan

B-12 Azolyl Quinoline-Urea Derivatives: A Novel Series of Potent Orally Active VEGF Receptor Tyrosine Kinase Inhibitors
Kubo K.,1 Suzuki R.,1 Kimura K.,1 Sakai T.,1 Hasegawa K.,1 Kobayashi Y.,1 Takahashi N.,1 Watanabe M.,1 Hirai M.,1 Nakamura K.,1 Taguchi E.,1 Takahashi K.,1 Kubo K.,1 Kanazawa M.,1 Matsunaga N.,1 Kamishohara M.,1 Shibuya M.2 and Isoe T.1
1: KIRIN Brewery Co., Ltd., Japan, 2: University of Tokyo, Japan

B-13 Silicon Containing Heteroaromatic Sulfides as Selective Cholesterol Level Lowering and Vasodilating Agents
Lukevics E., Abele E., Abele R., Rubina K., Veveris M. and Arsenyan P.
Latvian Institute of Organic Synthesis, Latvia

B-14 Synthesis and Biological Activities of 1,3-diazaspiro[4,5/4]dec/non-1-en-4-one Derivatives
Xu J.-Y., Li N.-G., Wu X.-M., Hua W.-Y., Zhang J. and Wang Q.-J.
China Pharmaceutical University, P.R. China

B-15 Synthesis, Structure and Biological Activity Relationship of E7080 and Its Derivatives as Novel and Potent Antiangiogenic Protein Tyrosine Kinase Inhibitors Including the VEGF Receptors, FGFR1 Receptor and PDGF Receptor
Miyazaki K., Tsuruoka A., Matsushima T., Haneda T., Fukuda Y., Kamata J., Takahashi K., Matsukura M., Watanabe T., Nomoto K., Obaishi H., Funahashi Y., Yamaguchi A., Nakamura K., Suzuki S., Mimura F., Yamamoto Y., Matsui J., Asada M. and Yoshimatsu K.
Eisai Co., Ltd., Japan

B-16 Synthesis and Pharmacological Profile of Aortic-Selective ACAT Inhibitors, K-10191
Shibuya K., Ohgiya T., Kawamine K., Miura T., Yoshinaka Y., Kobayashi H. and Tsunenari Y.
Kowa Company, Ltd., Japan

B-17 Cardioselective Anti-ischemic ATP-sensitive Potassium Channel(KATP) Openers: Benzopyranyl Indoline and Indole Analogues
Lee S.-K., Yi K.-Y., Suh J.-H., Kim N.-J., Lee B.-H. and Seo H.-W.
Korea Research Institute of Chemical Technology, Korea

B-18 Novel Indoline-based ACAT Inhibitors with Anti-oxidative Activity: Synthesis, Physicochemical and Biological Properties
Takahashi K., Shirahase H., Kamiya S., Ikai M., Kunishiro K., Kawai S. and Kanda M.
Kyoto Pharmaceutical Industries Ltd., Japan

B-19 Synthesis and Pharmacological Evaluation of 1-oxo-2-(3-piperidyl)-1,2,3,4-tetrahydroisoquinoline Derivatives as New Class of Specific Bradycardic Agents Possessing If Channel Inhibitory Activity
Kubota H., Watanabe T., Kakefuda A., Masuda N., Wada K., Ishii N., Sakamoto S. and Tsukamoto S.
Yamanouchi Pharmaceutical Co. Ltd., Japan

B-20 Design, Synthesis and Structure-Activity Relationship of Biphenylamidine Derivatives as Novel Factor Xa Inhibitors
Nakada T., Takano Y., Hara T., Sugiura S., Tsutsumi T., Takarada R., Koizumi M. and Takimoto-Kamimura M.
Teijin Ltd., Japan

B-21 Discovery and Development of Orally Active Factor Xa Inhibitors
Uchida M.1, Muranaka H.1, Nakano S.1, Ozawa T.1, Takeuchi H.1, Tsuji E.1, Kobayashi H.1, Kai Y.1, Yokoyama K.1, Terao Y.1, Mukaiyama H.1, Shiohara H.1, Isawa H.1, Kikuchi N.1, Koizumi T.1, Hoyano Y.1, Miyata H.1 and Murakami Y.2
(1) Kissei Pharmaceutical Co., Ltd, Japan, (2) Toho University, Japan

B-22 A Novel 1,3-dioxane-2-carboxylic Acid Derivative, NS-220, as a Highly Potent and Selective PPARα Agonist
Sugiyama Y., Aoki T., Asaki T., Hamamoto T., Tada S., Ohmachi S., Kuwabara K., Murakami K., Todo M., Ukai Y., Matsuura A. and Yano J.
Nippon Shinyaku Co., Ltd., Japan

B-23 Synthesis of New PPARγ Agonist without Thiazolidinedione Moiety
Miyata N.1, Hattori Y.1, Etoh K.1, Kohara A.1,2, Sudou T.2 and Kohda K.1
1Nagoya City University, Japan, 2Daiichi Pure Chemicals Co., Japan

B-24 Structural Requirement of Isoflavonones for the Inhibitory Activity of Interleukin-5
Jung S.-H., Cho S.-H., Lee J.-H., Hung D.-T., Ju J.-H., Kim M.-K., Lee S.-H., Ryu J.-C. and Kim Y.-S.
Chungnam National University, Korea

B-25 Application of Diels-Alder Reaction to Some 1-dehydrosteroidal Drugs and the Pharmacological Evaluation in Rats
Shamsa F., Sharifzadeh M., Ramazani F. and Mirzaee S.
Tehran University of Medical Sciences, Iran

B-26 Development of a Potent and Highly Selective Human Mast Cell Tryptase Inhibitor: Structure Activity Relationship on Ethylene Diamine Derivatives
Miyazaki Y., Kato Y., Manabe T., Shimada H., Mizuno M., Egusa T., Ohkouchi M., Shiromizu I., Matsusue T., Naba H., Ogihara T., Yamamoto I., Mizuguchi K. and Mochizuki H.
Mochida Pharmaceutical Co., Ltd., Japan

B-27 Synthesis and Biological Evaluation of Benzoxazole Derivatives as 5-lipoxygenase Inhibitors
1Park Choo H.-Y., 1Yoon J.-H., 2Chang H.-W. and 2Ju H.-K.
1Ewha Womans University, Korea, 2Yeungnam University, Korea

B-28 Discovery of Novel Imidazopyrimidines as Potent and Selective Inhibitors of Spleen Tyrosine Kinase
Yura T., Li Y.F., Yamamoto N. and Komura H.
Bayer Yakuhin Ltd., Japan

B-29 Topically Active Long-acting M3 Selective Antagonists for the Treatment of Obstructive Pulmonary Diseases
Yamakawa T., Ogino Y., Kurihara H., Ishikawa M., Matsuda K., Kobayashi K., Naya A., Numazawa T., Fujikawa T., Sakaizumi N., Kimura T., Noguchi K. and Ohtake N.
Banyu Pharmaceutical Co., Ltd., Japan

B-30 9-(2-hydroxy-4,4-dimethyl-6-oxo-1-cyclohexen-1-yl)-3,3-dimethyl-2,3,4,9-tetrahydro-1H-xanthen-1-one, a Selective and Orally Active Neuropeptide Y5 Receptor Antagonist
Sato N., Jitsuoka M., Shibata T., Hirohashi T., Nonoshita K., Moriya M., Haga Y., Sakuraba A., Okamoto O., Mashiko S., Ishihara A., Kanatani A. and Fukami T.
Banyu Pharmaceutical Co., Ltd., Japan

B-31 Design and Synthesis of Novel β-Secretase Inhibitor
Bae S.-J.*, Lee J.-S.*, Lee D.-W.**, Jeong M.**, Kim B.-M.**, Yoon S.-K.***, Cho Y.-L.*** and Oh Y.-S.***
* Promeditech, Inc., Korea, ** Seoul National University, Korea, *** LG Life Sciences, Ltd., Korea

B-32 The SAR of Simplified Resiniferatoxin Analogues as Potent VR1 Agonists Elucidates Their Active Conformation and Heterogeneity of Response to VR1
Park S.,a Kim S.-Y.,a Lim J.-O.,a Lee Ji.,a Kang M.,a Kang S.-U.,a Choi H.-K.,a Jin M.,a Lee J.,a Ha H.-J.,b Kim Y.-H.b and Blumberg P.-M.c
a Seoul National University, Korea, b Digital Biotech, Korea, c NCI, NIH, USA

B-33 N-(3-Acyloxy-2-benzylpropyl)-N'-[4-(methylsulfonylamino)benzyl]thiourea Analogues as High-affinity VR Antagonists
Kil M.,a Lee Ji.,a Kang S.-U.,a Choi H.-K.,a Jin M., Yoon H.-S.,a Lee J.,a Ha H.-J.,b Kim Y.-H.b and Blumberg P.- M.c
aSeoul National University, Korea, bDigital Biotech, Korea, cNational Cancer Institute, NIH, USA

B-34 N-4-Substituted-benzyl-N'-tert-butylbenzyl Thioureas as Vanilloid Receptor Ligands: Investigation on the Role of Methanesulfonamido Group in Antagonistic Activity
Park H.-G.,a Kim M.-J.,a Choi J.-Y.,a Choi S.-H.,a Park M.-K.,a Lee J.,a Suh Y.-G.,a Cho H.,a Oh U.,a Lee Ji.,a Kang S.-U.,a Lee Je.,a Kim H.-D.,b Park Y.-H.,c Jeong Y.-S.,c Choi J.-K. c and Jew S.-S.a
aSeoul National University, Korea, bSookmyung Women's University, Korea, cAmorePacific R & D Center, Korea

B-35 Synthesis, SARs and Biological Activities of Potent and Selective Group II mGluR Antagonists, Novel 2-Amino-6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic Acid Derivatives
Yasuhara A., Sakagami K., Ohta H., Yoshikawa R., Chaki S., Itoh M., Nakamura M. and Nakazato A.
Taisho Pharmaceutical Co., Ltd., Japan

B-36 4- or 5-Carbamoyl-1,2,3,6-tetrahydropyridino Heterocyclic Derivatives as CRF1 Receptor Antagonists
OkuboT.,1 Kumagai T.,1 Kennis L.,2 De Bruyn M.,2 Van Den Keybus F.,2 Van Roosbroeck Y.,2 Diels G.,2 Oshida Y.,2 Nakamura M.,2 Chaki S.,2 Okuyama S.,1 Mackie C.,2 Steckler T.2 and Nakazato A.1
1 Taisho Parmaceutical Co., Ltd., Japan. 2 Johnson & Johnson Pharmaceutical Research & Development, Belgium

B-37 4- or 5-Carbamoyl-1,2,3,6-tetrahydropyridino-Pyrrolopyrimidine Derivatives and -Quinoline Derivatives as CRF1 Receptor Antagonists
De Bruyn M.,2 Kennis L.,2 Okubo T.,1 Kumagai T.,1 Van Den Keybus F.,2 Van Roosbroeck Y., 2 Oshida Y.,1 Nakamura M.,1 Chaki S.,1 Okuyama S.,1 Mackie C.,2 Steckler T.2 and Nakazato A.1
1 Taisho Parmaceutical Co., Ltd., Japan 2 Johnson & Johnson Pharmaceutical Research & Development, Belgium

B-38 The SAR of Branched DAG-Lactones as High-Affinity Protein Kinase C Ligands
Kang J.,a Kim Y.,a Lee J.,a Lewin N.b and Blumberg P. M.b
aSeoul National University, Korea, bNational Cancer Institute, NIH, USA

B-39 Novel Protein Kinase C Inhibitors for the Prevention of Allograft Rejection: Synthesis, in vitro Activity and Pharmacokinetic Data
Albert R., Beerli Ch., Cottens S., Evenou J.-P., Sedrani R., von Matt P., Wagner J., Weckbecker G. and Zenke G.
Novartis Pharma AG, Switzerland

B-40 Synthesis of 6-Formyl-pyridine-2-carboxylate Derivatives and Their Telomerase Inhibitory Activities
Jew S.-S.,a Lee Y.-J.,a Park B.-S.,a Lim D.-Y.,a Chung I.-K.,b Kim J.-H.,b Hong C.-I.,c Kim J.-K.,c Park H.-J.,c Lee J.-H.c and Park H.-G.a
aSeoul National University, Korea, bYonsei University, Korea, cChong Kun Dang Pharmaceutical Co., Korea

B-41 Antiproliferative Activity of Catechins and Synthetic Peptides against Her2/neu-overexpressing Human Breast Cancer Cell Line SKBR3
Nagaoka Y. 1, Saiko K.1, Kobayashi S.1, Seto R.2, Hara Y. 2 and Uesato S. 1
1Kansai University, Japan, 2Tokyo Food Techno Co., LTD., Japan

B-42 Antitumor Effect of New Type Histone Deacetylase Inhibitors Possessing a Terminal Bicyclic Aryl Group and Its Molecular Mechanism
Uesato S.1, Nagaoka Y.1, Maeda T.1, Sowa Y.2, Sakai T.2 and Yamori T.3
1Kansai University, Japan, 2Kyoto Pref. Univ. Med., Japan, 3Cancer Chemotherapy Center, JFCR, Japan

B-43 Chloroalkylnitrosamines as Intercalating Cross-linkers
Ishikawa S. and Mochizuki M.
Kyoritsu College of Pharmacy, Japan

B-44 Development of Highly Potent Anti-Microtubule Agents Based on a Diketopiperazine Derivative Phenylahistin
Hayashi Y.,1 Tanaka K.,1 Oda A.,1 Kitagawa T.,1 Nicholson B.,2 Miller B.,2 Lloyd K.,2 Palladino M.2 and Kiso Y.1
1Kyoto Pharmaceutical University, Japan, 2Nereus Pharmaceuticals, USA

B-45 Novel Nuclear Vitamin D3 Receptor Agonists Having a Carborane Moiety
Songkram C.,a Yaguchi K.,a Tanatani A.,a Taodo Y.,a Yoshimi T.,a,b Kawachi E.,a Endo Y.a,b and Kagechika H.a
aThe University of Tokyo, Japan, bTohoku Pharmaceutical University, Japan

B-46 New Androgen Antagonists Bearing Boron Cluster as a Hydrophobic Pharmacophore
Endo Y.,1 Ohta K.,1 Goto T.,1 Fujii S.,2 Koiso Y.,2 Hashimoto Y.,2 Suzuki T. 3 and Ohta S.3
1Tohoku Pharmaceutical University, Japan, 2 University of Tokyo, Japan, 3Hiroshima University, Japan

B-47 Discovery of Novel Histone Deacetylase Inhibitors
Suzuki T1., Nagano Y1., Kohara A1, 2., Sudou T2., Kohda K1. and Miyata N1.
1 Nagoya City University, Japan, 2 Daiichi Pure Chemicals Co. Ltd., Japan

B-48 Inhibition of Protein Phosphatase 1 and 2A by Cantharidin Analogues
Thaqi A. a, McCluskey A.b and Scott J.L.a
aMonash University, Australia, bThe University of Newcastle, Australia

B-49 Development of Novel Azasugar Based Metalloproteinase Inhibitors
Moriyama H.,a,b Tsukida T.,a,b, Inoue Y.,b Kondo H.b, Yoshino K.b and Nishimura S.c
a Japan Bioindustry Association, Japan, b Nippon Organon K.K., Japan, c Hokkaido University, Japan

B-50 Cyclopropane-based Conformational Restriction of Histamine. (1S,2S)-2-(2-Aminoethyl)-1-(1H-imidazol-4-yl)cyclopropane, a Highly Selective Agonist for the Histamine H3 Receptor, Having a Cis-Cyclopropane Structure
Shuto S., Kazuta Y., Watanabe M. and Matsuda A.
Hokkaido University, Japan

B-51 Structure and Activity Relationships of Novel Pyrimidine Derivatives as Topical Anti-inflammatory Agent
Isobe Y., Tobe M., Inoue Y., Isobe M., Tsuchiya M. and Hayashi H.
Sumitomo Pharmaceuticals Co., Ltd., Japan

B-52 Design, Synthesis and Structure-activity Relationships of a Novel Class of Tricyclic Quinazoline-1,3(2H)-dione Derivative as Potent Poly(ADP-ribose) Polymerase-1 Inhibitors
Hasegawa H., Masumoto S., Ohtani K., Aino H. and Ohashi N.
Sumitomo Pharmaceuticals Co., Ltd., Japan

B-53 A Novel Metal-chelating Inhibitor of Protein Farnesyltransferase
Hamasaki A.,1 Naka H.,2 Tamanoi F.,3 Umezawa K.2 and Otsuka M.1
1Kumamoto University, Japan, 2Keio University, Japan, 3University of California, Los Angeles, USA

B-54 Studies on Orally Active Cyclic Peptide Motilin Antagonist
Sato T., Yoshino H., Kamei K. and Matsuoka H.
Chugai Pharmaceutical Co., Ltd., Japan

B-55 Studies on 16-ene-22-thiavitamin D3 Analogs as an Antipsoriatic Agent
Kawase A., Shimizu K., Mitsui T., Yamaguchi K., Matsushita T., Shimaoka S. and Morikawa K.
Chugai Pharmaceutical Co., Ltd., Japan

B-56 New Broad Spectrum Parenteral Cephalosporins Exhibiting Potent Activity against Both Methicillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa: Synthesis and Structure-activity Relationships in the S-3578 Series
Itani H., Ishikura K., Irie T., Yokoo K., Kubota T., Minami K., Yoshizawa H., Miwa H. and Nishitani Y.
Shionogi & Co., Ltd., Japan

B-57 Structure-Activity Relationships of Novel Piperidine Derivatives as Ras Farnesyltransferase Inhibitors
Nara S.1, Tanaka R.1, Yoda N.1, Eishima J.1, Hara M.1, Soga S.1, Akinaga S.1, Ohashi R.1, Kuwabara T.1, Foglesong R.J.2, Hughes P.F. 2, Turkington S.2 and Kanda Y. 1
(1) Kyowa Hakko Kogyo Co., Ltd., Japan, (2) Eli Lilly and Company, USA

B-58 Development of Small Molecules for γ-Secretase Inhibition
Hu M.-K.,1 Liao Y.-F.,2 Liao C.-Y.1 and Huang S.-Y.1
1National Defense Medical Center, Taiwan, 2Academia Sinica, Taiwan

B-59 Novel Synthesis of Flavonoids of Scutellaria baicalensis Georgi
Huang, W.-H. and Lee, A.-R.
National Defense Medical Center, Taiwan

B-60 Design, Synthesis, and SAR of New Chemical Class Kappa Opioid Receptor Agonists
Kawai K., Hayakawa J., Kawamura K., Matsuura H., Endo T. and Nagase H.
Toray Industries, Inc., Japan

B-61 Hyperforins of Hypericum perforatum as Potent Inhibitors of the Metabolic Enzyme Cytochrome P450 3A4
Lee J., Tran V.H., Duke R.K. and Duke C.C.
The University of Sydney, Australia

B-62 Quantitative Prediction of Transporter-mediated Drug-drug Interaction
Shitara Y.1, Hirano M.2, 3, Sato H.1 and Sugiyama Y.2
1 Showa University, Japan, 2 The University of Tokyo, Japan, 3 Kowa Co., Ltd., Japan

B-63 Gene Expression Resemblance between Macaca Monkey and Human, and Its Application for Environmental Toxicogenomics
Asaoka K.1, Iida H.1, Kamanaka Y.1, Nishimura T.1, Wakita M.1, Suzuki J.1, Watanabe K.1, Ishikawa Y.2, Kawashima S.2, Mori C.3, Yasuda M.4 and Kubota S.5
1 Kyoto University, Japan, 2 Tokyo Metropolitan Institute of Medical Science, Japan, 3 Chiba University, Japan, 4 Hiroshima International University, Japan, 5 The University of Tokyo, Japan

B-64 A Novel Antedrug Approach to the Discovery of Safer Anti-inflammatory Steroids
Lee H.-J., Park K.-K., Ko D.-H., You Z. and Cooperwood J.S.
Florida A&M University, USA

B-65 Characterization of Efflux Transport of Cephlosporins (Cefalexin and Cefaclor) from the CSF through the Choroid Plexus
Kusuhara H., Kuroda M. and Sugiyama Y.
The University of Tokyo, Japan

B-66 GAT-2/BGT-1 Plays a Complementary Role as a Taurine Transport System at the Blood-placenta Barrier
Kitano T.1), Hwang I.-W.1), 2), Hirose Y.1), Iizasa H.1), Terasaki T.3) and Nakashima E.1)
1) Kyoritsu College of Pharmacy, Japan, 2) Sookmyung Women's University, Korea, 3) CREST, Japan

B-67 The Rat Bone Marrow-derived Endothelial Cell Line, TR-BME, Differentiates into Vascular Smooth Muscle Cells
Miyata T.1, Fujii J.1, Iizasa H.1, 2, Asashima T.1, Terasaki T.2 and Nakashima E.1, 2
1Kyoritsu College of Pharmacy, Japan, 2CREST, Japan

B-68 The Rat Bone Marrow-derived Endothelial Cell Line, TR-BME, Differentiates into Neural-like Cells
Iida S.1, Iizasa H.1,2, Miyata T.1, Terasaki T.2 and Nakashima E.1,2
1Kyoritsu College of Pharmacy, Japan, 2CREST, Japan

B-69 Potential of Arginine-rich Peptides for Intracellular Delivery of Macromolecules
Futaki S.,1,2 Nakase I.,1 Niwa M.1 and Sugiura Y.1
1Kyoto University, Japan, 2PREST, JST, Japan

B-70 Translocation of a β-Peptide Across Cell Membranes
Umezawa N.1), 2), Gelman M.A.2), Haigis M.C.2), Higuchi T.1), Raines R.T.2) and Gellman S.H.2)
1) Nagoya City University, Japan, 2) University of Wisconsin, USA

B-71 Intracellular Delivery of Histidine-tagged Proteins
Futaki S., Niwa M., Wakako N., Nakase I., Shiraishi Y. and Sugiura Y.
Kyoto University, Japan

B-72 Membrane Permeable RNase S Complex Bearing Arginine-rich Peptides and Anti-HIV Activity
Futaki S., Nakase I., Niwa M., Suzuki T., Nameki D., Kodama E., Matsuoka M. and Sugiura Y.
Kyoto University, Japan

B-73 Expression Analysis of Breast Cancer Resistance Protein (BCRP/ABCG2) in a Conditionally Immortalized Syncytiotrophoblast Cell Line, TR-TBTs
Ishido N.1, Kitano T.1, Iizasa H.1,2, Terasaki T.2,3 and Nakashima E.1,2
1) Kyoritsu College of Pharmacy, Japan, 2) CREST of Japan Science and Technology Corporation, Japan, 3) Tohoku University, Japan

B-74 Lead Optimization of Some Fused Isosteric Heterocyclic Compounds as Topoisomerase II Inhibitors
Yalcin I., AKi-Sener E., Vildiz I., Temiz-Arpaci O. and Gulbas-Tekiner B.
Ankara University, Turkey

B-75 Design, Synthesis, and Evaluation of a Novel Diphenacoum-derived, Conformation-restricted Vitamin K 2,3-Epoxide Reductase Inhibitor
Chen D.-U., Kuo P.-U. and Yang D.-Y.
Tunghai University, Taiwan

B-76 Discovery of Potent Acetylcholinesterase Inhibitors with a Galanthamine Scaffold via Protein Structure-Based Design and Synthesis
Kimura T.,† Morita N.,‡ Nakamura Y.,‡ Arisawa M.,‡ Kakiguchi K.,‡ Kita Y.,‡ Kaneko T. † and Miyamoto S. †
†Sankyo Co., Ltd., Japan, ‡Osaka University, Japan

B-77 Solid-Phase Synthesis of DAPT Derivatives and Their γ-Secretase-Inhibitory Activity
Kan T., Tominari Y., Rikimaru K., Morohashi Y., Natsugari H., Tomita T., Iwatsubo T. and Fukuyama T.
University of Tokyo, Japan

B-78 Rational Approaches to Discovery of PARP Inhibitors
Hattori K., Miyake H., Yamamoto H., Ishida J., Kido Y., Kamijo K., Murano K., Ohkubo M., Kinoshita T., Iwashita A. and Mihara K.
Fujisawa Pharmaceutical Co. LTD., Japan

B-79 Development of Potent β-Secretase Inhibitors Containing a Hydroxyethylamine Dipeptide Isostere and Their SARS
Kato T., Tamamura H., Otaka A. and Fujii N.
Kyoto University, Japan

B-80 Rational Discovery of GABAnergic Drugs
Oswal R.J. and Kadam S.S.
Bharati Vidyapeeth Deemed University, India

B-81 Design and Synthesis of Transition-state Mimic β-Secretase Inhibitors Based on the Structure of Amyloid Precursor Protein (APP)
Kimura T.,1 Shuto D.,1 Kasai S.,1 Liu P.,1 Hidaka K.,1 Abdel-Rahman H.M.,1 Igawa N.,1 Nagamine A.,1 Hamada T.,1 Shibakawa S.,1 Hayashi Y.,1 Hattori C.,2 Szabo B.,2 Ishiura S.2 and Kiso Y.1
1Kyoto Pharmaceutical University, Japan, 2University of Tokyo, Japan

B-82 Platform for Drug Discovery by Grid Technology: Combinatorial Computing and Integrated DB for Drug Design
Chuman H.1, Nagashima U.2, Ito M.2, Inadomi Y.2, Goto H.3, Boku T.4, Sato M.4 and Inagaki Y.5
1University of Tokushima, Japan, 2National Institute of Advanced Industrial Science and Technology, Japan, 3Toyohashi University of Technology, Japan, 4University of Tsukuba, Japan, 5Fuji Research Institute Corporation, Japan

B-83 Preparation of Antibody Against a Novel Immunosuppressant, FTY720 and Development of an Enzyme Immunoassay for FTY720
Matsumoto N.,1,2 Kohno T.,1 Uchida S.,1 Shimizu T.,1 Kusumoto N.,1 Yanada K.,1 Kurio W.,1 Watabe K.,1 Hirose R.2 and Fujita T1,3
1 Setsunan University, Japan, 2Taito Co. Ltd., Japan, 3Research Institute for Production Development, Japan

B-84 A New Research Strategy for IV α-cytosolic Phospholipase A(2) Inhibitors with Anti-inflammatory Activity: The Renaissance in Medicinal Chemistry
Kubota-Takagi M., Ishimitsu K., Nagano Y., Oshio I., Yagihara T., Suga S., Suzuki T. and Takeuchi I.
Nippon Soda Co., Ltd., Japan

B-85 Development of a Maillard Reaction Inhibitor, Plantagoside
Matsuura N., Ubukata M., Kojima H.*, Ohara M.* and Hasegawa J.*
Toyama Prefectural University, Japan, *Ichimaru Pharcos Co., Ltd., Japan

B-86 Modification of Intracellular Ca2+ Dynamics by Laser Inactivation of Inositol 1,4,5-trisphosphate Receptor Using Membrane-permeant CALI Probes
Yogo T.1, Kikuchi K.1, 2, Inoue T.1, Hirose K.1, Iino M.1 and Nagano T.1
1The University of Tokyo, Japan, 2Presto, JST Corporation, Japan

B-87 Development of Novel Fluorescence Resonance Energy Transfer Probes for Ratiometric Measurement of Protein Tyrosine Phosphatase Activity
Takakusa H.1, Kikuchi K.1,2 and Nagano T.1
1University of Tokyo, Japan, 2Presto, JST Corporation, Japan

B-88 Development of Selective, Visible Light-excitable, Fluorescent Magnesium Ion Probes with a Novel Fluorescence Switching Mechanism
Shoda T. a, Kikuchi K. ab, Komatsu H. c, Suzuki K. c and Nagano T.a
aThe University of Tokyo, Japan, bPRESTO, JST Corporation, Japan, cKeio University, Japan

B-89 Transcriptomic and Proteomic Analyses for Profiling a Novel Sulfonamide Anticancer Agent Indisulam (E7070)
Owa T., Yokoi A., Kuromitsu J., Sato T., Katayama H., Oda Y. and Nagasu T.
Eisai Co., Ltd., Japan

B-90 The High Affinity Interaction of Phosphodiesterase 5 and Its Inhibitor Chemical Probe Correlates with the Potent Inhibitory Activity: The Basis of Novel Drug Discovery Program, Chemical-targeted Proteome
Takase Y., Agarwala K.L., Oda Y., Kato H., Sato T. and Nagasu T.
Eisai Co., Ltd., Japan

B-91 Development of Novel Lanthanide Complexes as a Magnetic Resonance Imaging (MRI) Contrast Agent
Hanaoka K. 1, Kikuchi K. 1,2 and Nagano T. 1
1 The University of Tokyo, Japan, 2 Presto, JST Corporation, Japan

B-92 Diversity-Oriented Synthesis of Natural Product-like Macrocycles towards Chemical Genetics
Nakai K. *1 and Schreiber S.L.*2
*1 Fujisawa Pharmaceutical Co., Ltd., Japan, *2 Harvard University, USA

B-93 Synthesis of Carboxylic Acid Libraries
Nukui S.1), Peguet W.2), Ohta A.1) and Kawai A.1)
1)Pfizer Global Research & Development, Japan, 2) Lyon School of Chemistry, CPE, France

B-94 Molecular-size Reduction of a Potent CXCR4 Antagonist Using Orthogonal Combination of Conformation-based and Sequence-based Libraries
Ueda S.,1 Araki T.,1 Hiramatsu K.,1 Oishi S.,1 Tamamura H.,1 Otaka A.,1 Kusano S.,2 Terakubo S.,2 Nakashima H.,2 Wang Z.,3 Peiper S.C.3 and Fujii N.1
1Kyoto University, Japan, 2St. Marianna University, Japan, 3Medical College of Georgia, USA

B-95 Isotaxel: A Novel Water-soluble Paclitaxel Prodrug
Hayashi Y., Skwarczynski M., Hamada Y., Sohma Y., Kimura T. and Kiso Y.
Kyoto Pharmaceutical University, Japan

B-96 Development and Biological Application of Novel Fluorescence Probes that can Reliably Detect Reactive Oxygen Species and Distinguish Specific Species
Setsukinai K.1, Urano Y.1, Kakinuma K.1, Majima H.J.2 and Nagano T.1
1 The University of Tokyo, Japan, 2 Kagoshima University, Japan

B-97 Rational Design of Functional Fluorescein-based Fluorescence Probes
Ueno T., Urano Y., Kanda K., Miura T. and Nagano T.
The University of Tokyo, Japan

B-98 Discrimination of Enantiomers by Means of NMR Spectroscopy using Chiral Liquid Crystalline Solution - Application to Triazole Fungicides, Uniconazole and Diniconazole -
Sugiura M., 1 Kimura A.2 and Fujiwara H.2
1Kobe Pharmaceutical University, Japan, 2Osaka University, Japan

B-99 Rational Design of Highly Sensitive Fluorescence Probes for Nitric Oxide Based on Boron Dipyrromethene Chromophore
Gabe Y., Urano Y. and Nagano T.
The University of Tokyo, Japan

B-100 The Investigation of the Interrelation between Biological Activity and the Structure of Monoethers of Alicyclic Dicarboxylic Acids
Mamedov E.G., Gasanov A.G., Aliyeva L.I., Ayyubov I.G. and Gurbanova M.M.
IPCP NAS, Azerbaijan

B-101 In vivo ESR Measurement of Radical Generation in Mouse Skin under Ultraviolet Light
Takeshita K.1, Chi C.1, Hirata H.2, Ono M.2, Suzaki H.2 and Ozawa T.1
1 National Institute of Radiological Sciences, Japan, 2 Yamagata University, Japan

B-102 A Medicinal Chemistry Approach to Link Receptor Sequence with Drug Design
Crossley R., Stevens A., Slater M., De Zoysa P., Lipkin M. and Ravi N.
BioFocus Discovery, UK

B-103 Discovery of a Highly Selective Serotonin 5-HT2A Antagonist
Crossley R.1, Barker E.1, Bushfield M.1, Sciammetta S.1, Cholleton N.1, Laouar N.1, Stevens A.1, Hornigold D.1, Frearson J.1, Smith L.1, Calvert G.1, Hedgecock C.2, Berthold M.2, Nilsson J.E.2, Jenmalm-Jensen A.2 and Lindmark T.2
1BioFocus Discovery, UK, 2Biovitrum, Sweden

B-104 Bringing Kinases SAR into Focus
Stevens A.P., Rose S., Lipkin M., Church N., Harris C.J., Sherborne B., Birault V., Marsden B. and Nerella R.
BioFocus Discovery Ltd., UK

B-105 Molecular Docking and 3D-QSAR Study of Methionyl-tRNA Synthetase Inhibitors
Kim S.Y. and Lee J.
Seoul National University, Korea

B-106 Protein Splicing in Yeast Vma1 Homing Endonuclease Protein: Crystal Structures of the Precursor and Products
Mizutani R.1, Anraku Y.2 and Satow Y.1
1University of Tokyo, Japan, 2Teikyo University of Science and Technology, Japan

B-107 The Structure and Function of Human Dipeptidyl Peptidase IV (DPPIV), Possessing a Unique Eight-bladed β-Propeller Fold
Yamamoto A.1, Hiramatsu H.1, Kyono K.1, Higashiyama Y.1, Fukushima C.1, Shima H.1, Sugiyama S.2, Inaka K.2 and Shimizu R.1
1Tanabe Seiyaku Co. Ltd., Japan, 2Maruwa Foods Co., Ltd., Japan

B-108 Analysis of the Structure of the Kinase Domain of the Stem Cell Factor Receptor Tyrosin Kinase (c-Kit) - Constitutive Activation by a D816V Mutation and Inhibition by STI571
Ashman L., Ferrao P., Foster R. and Griffith R.
University of Newcastle, Australia

B-109 Optimization Strategy for Chemical Database Screening to Discover New Histone Deacetylase Inhibitors
Yoo J.-K., Jung Y.-H., Zee O.-P. and Park H.-J.
Sungkyunkwan University, Korea

B-110 Comparative Design of Human Cathepsin A Inhibitor based on Bioinformatics of Homologous Serine Carboxypeptidases
Itoh K.1, Satoh Y.1, Oheda Y.1, Kadota Y.1, Tatano Y.1, Kuwahara J.1, Yoshida T.1, Chuman H.1, Aikawa S.2, Matsuzawa F.2 and Doi H.2
1The University of Tokushima, Japan, 2Celestar Lexico-Sciences, Inc., Japan

B-111 Crystal Structure of the Human Tissue Factor Complex with Its Cognate Humanized Antibody Fab: Structural Basis for the Inhibition of Blood Coagulation
Ohto U.1, Mizutani R.1, Nakamura M.2, Adachi H.2 and Satow Y.1
1 University of Tokyo, Japan, 2 Chugai Pharmaceutical Co. Ltd., Japan

B-112 Study of Species Differences in Ligand-dependent PPARα Activation by Molecular Modeling and Site-directed Mutagenesis
Uchiki H. and Miyachi H.
Kyorin Pharmaceutical Co., Ltd., Japan

B-113 Prediction of Biological Targets Using Probabilistic Neural Networks and Atom-type Descriptors
Niwa T.
Nippon Shinyaku Co., Ltd., Japan

B-114 Discovery of Novel RNA-binding Ligands by Virtual Screening and -1 Ribosomal Frameshifting Assay
Park S.-J.1, Kim Y.-G.2, Jung Y.-H.1, Ham W.-H.1 and Park H.-J.1
1Sungkyunkwan University, Korea, 2Chung-Ang University, Korea

B-115 Validation for Virtual Screening Tools and Its Applications in BMD TIC
Nam K.-Y., Shin J.-H., Kim H.-J., Cho Y.-K., Lee C.-J., Kim J.-S. and No K.-T.
Bioinformatics and Molecular Design Research Institute, Korea

B-116 Developing Virtual Screening Program for PC Grid Computing
Cho Y.-K., Lee C.-J., Nam K.-Y. and No K.-T.
Bioinformatics & Molecular Design Research Technology Innovation Center, Korea

B-117 New Program for the Prediction of ADME Drug Properties: PreADME
Lee S.-K., Lee I.-H., Chang G.-S., Chung J.-E., Sung K.-Y. and No K.-T.
Bioinformatics & Molecular Design Research Technology Innovation Center, Korea

B-118 Synthesis and 3-D QSAR Studies on Thiourea Antifungal Agents
Thai K.-M.1, Huynh P.N.T.2, Truong P.2, Ham W.-H.1, Jung Y.-H.1 and Park H.-J.1
1Sungkyunkwan University, Korea, 2University of Medicine and Pharmacy, HoChiMinh, Vietnam

B-119 Multi-Drug-Resistance Mutations in HIV-1 Protease
Ohtaka H. and Freire E.
The Johns Hopkins University, USA

B-120 QSAR Analysis and Prediction of Drug Excretion into Human Breast Milk
Yamauchi A., Fujiwara T., Kihara M. and Chuman H.
The University of Tokushima, Japan

B-121 Design and Synthesis of 4-Anilinobenzotriazines as VEGF Receptor Tyrosine Kinase Inhibitors
Zhao L.-X., Hu Q.-Z., Wang J.-L. Yin L.-N. and Wang X.
Shenyang Pharmaceutical University, P.R. China

B-122 Preparation and Opioid Receptor Profiles of 1-Aralkyl-4-(N-phenyl-N-propanoylamino)piperidine-4- carboxylates and Related Compounds
Iwamura T.1, Usami K.1, Tanaka D.1, Kataoka T.1, Nakagawa T.2, Minami M.2 and Satoh M.2
1Gifu Pharmaceutical University, Japan, 2Kyoto University, Japan